Cushing's syndrome is a term used to talk all about the effects of stress hormone cortisol. The exceed secretion of this hormone can cause some negative conditions, particularly hypercortisolism, for the both of men and women, especially under the ages of 25 to 40. It is fortunate that Cushing's syndrome can be treated even though it takes a period of time for these symptoms to ease up. And finding the suitable treatments for Cushing’s syndrome is very important indeed.
The main cause of Cushing's syndrome is the too much secretion of cortisol that comes from the adrenal grand and sits on top of the kidneys for a long time. Another cause involves in the medications called glucocorticoids that are known as prednisone or steroids. These prescription steroids, commonly used in cases of rheumatoid, asthma, lupus, arthritis, or organ transplant, are so powerful anti-inflammatory that they can cause Cushing's syndrome in a long- term usage. The symptoms of Cushing’s syndrome differ from each other including high blood pressure, kidney stones, osteoporosis, weight gain particularly upper body, rounded and rosy face with acne, thin arms and legs, weak muscles especially in shoulders and hip, depression and anxiety, or low sex drive…
At present, VKool.com would like to recommend top 4 alternative treatments for Cushing’s syndrome in humans. Besides 4 professional and effective treatments for this condition, health information about it is also exhibited. For those are suffering from the Cushing’s syndrome, take a look at our article know and understand its symptoms and treatments to deal with it completely.
Top 4 Alternative Treatments For Cushing’s Syndrome In Humans
1. Reduce Corticosteroid Use
One of the best natural treatments for Cushing's syndrome is reducing the use of corticosteroid. Reducing the usage of corticosteroid is known as an important way of the treatments for Cushing’s syndrome. It is because the long- term usage of corticosteroid medication can be the cause of this disorder. In such cases, you have to reduce the dosage for a period of time in order to keep the Cushing symptoms and signs under control. However, you have also to maintain using this drug because of arthritis, asthma, or other condition management. The way on how to reduce the intake of corticosteroid depends on the instructions of medical professionals.
There are 2 points you have to pay attention:
- Don't stop using or reduce an exceed dose of corticosteroid drugs on your own but do so under the supervision of the doctors.
- Dramatically discontinuing the corticosteroid medication can cause cortisol deficiency. Therefore, just slowly taper these corticosteroid drugs off to keep your body resuming normal cortisol production.
Surgery is known as another of the treatments for Cushing’s syndrome, which is used in case its cause is a tumor. All the surgical removal is completely recommended by the professional doctors. Pituitary tumors may be the typical cause that is eliminated by a neurosurgeon who conducts the surgical procedure through the nose. In addition, if a tumor appears in the lungs, pancreas, or adrenal glands, the surgeon can use minimally invasive surgical techniques to remove it, just with small incisions.
When the surgery is completed, the patients have to take cortisol replacement medications so that their bodies are provided with the enough amount of cortisol. It is unavoidable that the normal adrenal hormone production returns, commonly after 1 year or more, and you then receive a decreased replacement drugs. That means they need an effective lifelong replacement therapy.
Now are 3 detailed cases of surgery treatments for Cushing’s syndrome:
Tumor in pituitary gland:
The surgical procedure on removing a tumor existing in the pituitary gland is called transsphenoidal adenectomy. Under the effect of anesthesia, the pituitary tumor of the patient is removed through the nostril or an opening on the upper lip.
In fact, this type of surgery retains a high record of success with 80% of the cases with 10 mm or smaller pituitary tumor is cured. The cure rate is down to 50% for the larger tumors. And if the first operation doesn’t succeed, a second one is additionally recommended.
Tumor in adrenal gland:
Laparoscopic surgery is named as the surgical procedure on removing a tumor in the adrenal gland. And there is often only one adrenal gland needed to be removed indeed. In this procedure, a small incision is made in the abdomen then the adrenal gland is removed with tiny instruments by the surgeon.
This laparoscopic surgery gives less painful feelings after the operation, which is known as an advantage of the treatments for Cushing’s syndrome. This type of surgery also has a great record of success, which is examined that more than 65% of its symptoms is completely cured.
There can be some more complex cases in which both of the adrenal glands must be in the surgical so they are impossible to produce any cortisol. These cases occur when the Cushing's syndrome symptoms are out of the control and bring other long- term health risks. And high blood pressure or hypertension is considered as such a poor control case.
Tumor in lung:
When the tumor appears in the lung, the treatments for Cushing’s syndrome become more difficult. It is because we cannot remove or it safely without any damage to the lung.
In this case, using cortisol-inhibiting medication or adrenal gland removal is recommended instead of going on a surgery in order to stop the cortisol production.
3. Radiation Therapy
Radiation therapy is known as another of the treatments for Cushing’s syndrome, which is used when the surgeon cannot remove a pituitary tumor completely. In this case, a radiation therapy is applied in combination with the operation. Plus, this therapy is also used for those who do not have enough essential condition to go on a surgery. It abuses high- energy X-rays to minimize the tumor and prevent it from secreting adrenocorticotropin hormones.
In fact, the normal radiation therapy is daily used in small doses for a period of 5 weeks, which aids in reducing the damage to other brain areas. Besides, another type of radiation therapy that is called stereotactic radiosurgery is now increasingly used to remove pituitary tumors. This therapy applies a range of movable frames to keep the head in a defined position while a computer sends energy rays to shrink the pituitary tumor. The main target of stereotactic radiosurgery is to minimize the risks other brain parts being dramatically damaged and its whole dose is given just in one session. Particularly, this therapy is only available at some specialized centers, you may have to travel to gets the treatments for Cushing’s syndrome.
Both of the above- mentioned radiation therapy have advantages as well as disadvantages. They give good treatments for Cushing's syndrome but their effects are slow even for several months to years to get the full effect.
Medications are other treatments for Cushing’s syndrome, which is used to regulate the production of cortisol if both surgery and radiation cannot work. They are applied for a short term prior to a surgery or after this procedure and radiotherapy in order to support more effective treatments. Particularly, for those who are very sick because of Cushing’s syndrome, medications before surgery are very important that they are recommended by doctors to minimize risks and improve signs and symptoms. And there are cases in which the cortisol- inhibiting medications are applied for a long term in people unable to go on a surgery.
Metyrapone (Metopirone), mitotane (Lysodren), ketoconazole (Nizoral) are known as the medications for controlling the production of cortisol in the adrenal gland. Of the 3 medications, metyrapone and Ketoconazole are more widely used. In fact, Ketoconazole is mainly used to treat fungal infection and not considered as an official one of the treatments of Cushing's syndrome, it is added to the medications of this condition due to its good effectiveness.
For the patients with Cushing’s syndrome who are suffering from glucose intolerance or type 2 Diabetes, Mifepristone (Korlym) is highly recommended. This medication does not reduce the cortisol production but blocks its effect on body tissues. All of the 4 above medications have side effects including swelling, low potassium, headaches, muscle aches, fatigue, vomiting, nausea or even more serious condition like liver toxicity and neurological problems.
On the studies of treatments for Cushing’s syndrome, a new medication known as pasireotide (signifor), is proved. This medication reduces the production of adrenocorticotropin hormones from a pituitary tumor. It is delivered in the form an injection twice a day and used when the pituitary surgery is not successful or impossible to go on. Pasireotide medication also has several side effects including abnormal pains, headaches, high blood sugar, diarrhea, nausea, and fatigue.
There is sometimes the deficiency of other hormone production from the adrenal gland or pituitary because of the tumor or the treatment. Therefore, the doctors have to recommend additional medications of these hormones. And if all of the above treatments for Cushing’s syndrome do not act well, the surgical removal of adrenal glands is finally recommended, which cures the excess cortisol production but requires lifelong replacement medications.
Recommended article: How to reduce cortisol levels in the body – 11 tips
After reading our article on top 4 alternative treatments for Cushing’s syndrome in humans in our main Health page, hope that you all can understand how Cushing’s syndrome expresses and how to treat them effectively. It is advised to consult your doctors or medical professionals before going on these suggested treatments. And if you have any question, please leave them below and share with us other treatments for Cushing’s syndrome if you get more.